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Young Plasma vs PRP
Dian Ginsberg, MD FACOG ABAARM
PRP is defined as an autologous preparation of platelets in a small volume of plasma. Using the plasma of older patients to provide their healing is suboptimal as opposed to injecting young plasma with young growth factors.
Mechanism
Following aggregation and activation in response to vascular injury, platelets aid in tissue healing and regeneration by releasing GFs and other proteins that are stored in a-granules of platelets.
Growth Factors released by platelets that are thought to participate in healing processes:
https://www.sciencedirect.com/science/article/pii/S1578219014003357
Data indicates that that cell proliferation and migration of the oxidative stress-induced senescent vascular smooth muscle cells are desensitized to stimulation by platelet-derived growth factor (PDGF)-BB. These findings indicate that the milieu or the “exposome”(what completely bathes the vascular tissues) are of extreme importance if musculoskeletal damage is going to be reversed and healed.
Endothelial Cells from the brain, liver, and visceral fat illustrated an accelerated ageing cell types suggesting that continuous and direct exposure to the aged circulatory system induces strong transcriptomic changes. Endothelial Cells across all tissues seem susceptible to blood-borne influences and young plasma reversed aspects of ageing, especially in capillary endothelial cells. (1).
Using “Older” plasma to heal injuries has had inconsistent results since the necessary growth factors decrease with statistical significance in aging. The study below illustrates a significant drop in the number of growth factors important in the joint healing process.
(https://pubmed.ncbi.nlm.nih.gov/25003868/)
Platelet Derived Growth Factor – BB decreases significantly across age:
https://www.researchgate.net/publication/257467546_Age-Related_Changes_of_Chondrogenic_Growth_Factors_in_Platelet-Rich_Plasma
Young Fresh Frozen Plasma is Superior to PRP
Young plasma benefits—excerpts from the Wyss-Coray lab at Stanford:
Intriguingly, we observed an almost universal loss of gene expression with age…aged blood reduces global gene expression, and young blood restores it.
- Immune cell accumulation in adipose depots is a fundamental feature of ageing, and indeed most types, including T cells, B cells, neutrophils, and plasma cells, accrue across diverse organs
- 1,000 hematopoietic stem cells genes are altered by young blood, perhaps indicating a tight-knit relationship between ageing of the immune system and changes in blood composition.
-Rejuvenation appears to be a much more concerted process: the core network of ageing rescued by rejuvenation consists of mitochondrial electron transport chain genes for multiple cell types
Young plasma benefits—excerpts from the Wyss-Coray lab at Stanford: Intriguingly, we observed an almost universal loss of gene expression with age…aged blood reduces global gene expression, and young blood restores it.
-young blood is a potent instigator of mitochondrial function
- mitochondrial genes arise even for cell types in which age-related decline is not evident, like marrow monocytes supporting the notion that young blood may indeed broadly enhance mitochondrial function.
Overall, these data indicate that nearly all cell types are amenable to reformation via changes blood composition, even those not directly exposed to blood.
1. Chen, M. B. et al. Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues. Cell Rep. 30, 4418-4432.e4 (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292569/
2. PRP a bust in placebo-controlled trial for knee OA https://www.physiciansweekly.com/platelet-rich-plasma-a-bust-in-placebo-controlled-trial-forknee-oa
KEEPING IT SIMPLE SAFE SCIENTIFIC®
young Fresh Frozen Plasma (yFFP®) is prescribable from Spectrum Plasma, Inc.
137 N Guadalupe Street, San Marcos, Texas
512 518-6262
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