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Dian Ginsberg, MD RAADfest 2023:
Young Plasma Infusions and Longevity
Reversing the Aging Clock
Video Outline and Timestamps
3:30 Aging adheres to the “Laws of Entropy” 9:00 Young Plasma supports rejuvenation 10:30 Simply add-in young factors 11:00 Young blood reverses age related profiles 13:30 Benefits of young Fresh Frozen Plasma (yFFP®) 14:00 Case studies of Human Outcomes with yFFP
Learn More about Theraputic Plasma Treatment
Young Plasma Has Healing Abilities
Intravenous plasma from young donors could potentially treat Parkinson’s and other neurodegenerative diseases as well as offer anti-aging therapeutics. Young fresh frozen plasma yFFP® contains the perfect blend of vital proteins, anti-oxidants and extracellular vesicles (EVs)- able to rejuvenate body and brain tissues and fight the diseases of aging
BENEFITS
There are currently many scientific studies showing yFFP® recipients having statistically significant improvements, this site provides important information for doctors and patients interested in becoming part of further studies
RESEARCH DATA
This site strives to be an important resource providing the most significant research data gathered to date, on the studies and observations that have been conducted thus far on yFFP® (young plasma)
SAFETY
Plasma use has a well documented safety record and has been used for over 100 years in medicine. Using plasma with the most comprehensive testing from healthy college-aged students-brings a winning combination of SAFETY and HEALING
2019 Intravenous Plasma
Treatment for Parkinson's Disease (yFFP®) Study
The yFFP® Treatment for Parkinson's Disease & MS Study is the First of its Kind
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Kicked off in November of 2018
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Occurred in Houston's Texas Medical Center
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Study is double-blind and placebo controlled
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17 Parkinson's Disease participants
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20 Multiple Sclerosis participants
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Non-placebo participants received 25mg/kg of yFFP®
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Results througout the study course were presented at A4M World Congress
VIEW FULL PARKINSON'S STUDY AT:
DOWNLOAD PDF OF PARKINSON'S STUDY HERE:
ONGOING Investigational yFFP® Treatments Study YP042022
This study tracks the impact of yFFP over a wide spectrum of conditions...
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Study approved in 2022
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Treatments CURRENTLY occurring in clinics throughout TX
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Employs Epigenetic Methylation and Genomic testing and blood laboratory parameters
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Tracking biologic age shifts and genome changes
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Using sex and blood-typed Fresh Frozen Plasma from donors 18-25 years old, drawn at an AABB-accredited facility
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Study subjects receive 2 or 3 liters of yFFP within 30 days
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Therapeutic uses across a wide spectrum of conditions including Parkinson's, Alzheimer’s, metabolic syndrome and cardiovascular disease
LINK TO THE REVIEW BOARD:
DOWNLOAD PDF OF THE PROTOCOL HERE:
2019 Parkinson's Study Results
25-ml of yFFP® per kg of bodyweight administered in two doses over three days, realized statistically significant improvements in this disease-condition.
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Young blood plasma, collected from sex-identified individuals between the ages of 18-25, reverses age-related profiles and initiates systemic rejuvenation
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yFFP® recipients saw improvements in UPDRS and Stanford Presenteeism Scores
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Critical disease-related conditions such as fatigue, depression, and activities of daily living vs control saw statistically significant improvements
Dr. Dian Ginsberg Presentation:
Young Plasma Treatment and Reversing the Epigenetic Clocks: New Research and Clinical Applications
Video Outline and Timestamps
Introduction: 1:00 What is Epigenetic aging? 2:20 Changes in proteome across lifespan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062043 3:30 Transfused Blood Stem Cells Keep their age https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413751 5:05 Appears blood/plasma affect all tissues https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787543 5:50 Young Blood improves synaptic plasticity and cognitive function in mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224436 8:15 Aged blood reduces global gene expression, young blood restores it and mitochondrial function https://www.nature.com/articles/s41586-022-04461-2 9:35 Implications of Exchange https://www.ncbi.nlm.nih.cog/pmc/articles/PMC8050203 11:20 Adverse risk data https://pubmed.ncbi.nlm.nih.gov/11746539 12:06 FDA Safety Data Https://www.fda.gov/media/160859/download 13:09 Ambar Study Data: peripheral access safer than central access https://www.ncbi.nlm.nih.gov/articles/PMC/984263 13:39 Complications related to central line, why straight IV of plasma or mini exchange has better results www.ncbi.nlm.nih.gov/pmc/articles/PMC4613416 14:27 YBP on cardiac stem cells: Significant increased proliferation capacities and decrease of senescent cells Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349155 15:50 Supporting cells with young factors so they can clean themselves out and epigenetics improve https://www.fightaging.org/archives/2017/11/geroscience-interviews-michael-fossel-on-the-subject-of-telomeres-and-aging 17:22 How does Young Plasma make a difference? Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234057Joint and cartilage repair and growth factors:Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1184203 Brain growth factors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746393 18.41 Effect of YBP administration on gut microbiota in middle-aged rats (Aug. 2022) https://doi.org/10.1007/s00203-022-03154-8 20.09 Past yFFP patients have reported clinical improvements in Eczema, sleep and overall sense of well being, autoimmune Graves’ - ophthalmic disease and peripheral neuropathy, blood glucose and diabetes, degenerative arthritis, lower spine and back pain, muscle pathology, improvement of erectile dysfunction, eyesight improvement 21.38 How does plasma help minimize the disease of aging?Https://onlinelibrary.wiley.com/doi/10.1111/acel.13696 22.33 Overview of Parkinson’s Study Texas Medical Center 23.26 Results Parkinson’s Study 24:30 Individual Patient Clinical and Epigenetic Data 28:00 Pace of Aging slowed by 3.5% 28:22 Mini-Me Exchange (smaller 1 liter out and 1 liter yFFP in) 31:31 Dunedin Pace of aging slowed 31% in one participant 32:13 Patient B improvements at 2, 4, and 12 weeks, 5 year reversal of GrimAge 34.23 Overview of Latest and Ongoing Study: Investigational yFFP 25 ml per kg Treatments Study YP042022 35.55 Summary and closing remarks
What Does Plasma Contain?
Some Benefits of Plasma from Young Donors (yFFP®)
ARTICLES / PAPERS WRITTEN OR CONTRIBUTED BY DR. DIAN GINSBERG
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Enhanced Immune Factors and Hormones: Younger plasma may contain a higher concentration of immune-related proteins and antibodies, potentially offering better support to the microbiome and hormones
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Wound and Joint Healing: Increased presence of growth factors and regenerative proteins in yFFP® could promote tissue repair and wound healing in patients with injuries or chronic wounds:
Additional Research
Additional studies where Young Plasma's unique properties might provide therapeutic advantages
History of Plasma
Plasma is regulated by the FDA under rules delineated in 21 CFR 640. Plasma has been in continuous use since the 1920s, and its general safety and efficacy has long been proven.
Plasma used for our studies is sourced from a state-of- the-art Apheresis Center that conducts the most comprehensive testing on volunteer donated plasma from healthy college-aged students-brings, a winning combination of SAFETY and HEALING
Highest Quality Source of yFFP®
The American Red Cross estimates 6,500 units of plasma are used daily in the United States
Study using yFFP® in patients with AD demonstrate that treatment with yFFP is safe and warrants further exploration
COVID-19 Vaccines & Risk
Receiving a plasma or platelet transfusion from donors who had a prior COVID-19 infection or who have been vaccinated against COVID-19 does not increase the risk of adverse outcomes, according to the results of a new study from Kaiser Permanente Northern California (KPNC). The study, published Feb. 26 in Transfusion, found no link between these transfusions and an increased risk of thrombosis, respiratory complications or hospital mortality.
What is The Dilution Solution®?
Donating plasma is safe and beneficial for young people. Four small donations in a month is volume equivalent to a Theraputic Plasma Exchange, as it promotes neurogenesis and longevity
In 2020 and 2021, the FDA reported NO fatalities from plasma transfusions.
BEGINNINGS
Plasma was first used in the 1920's as a life-saving medicine in US surgical procedures following World War I
yFFP Revolution
In the 1950s a young mouse and an older mouse were sutured together in what's called "Parabiosis". The older mouse improved in both cognitive and physical measurements
"YOUNG" DONORS DEFINED
Plasma from "Young" Donors is best defined as FFP collected from a donor between the ages 18-25
TODAY
2.1 Million transfusions of plasma were given in 2019 and only one plasma-related (and completely avoidable fatality) occurred. There were no fatalities in 2020 and 2021.
Plasma News & Publications
Press Releases
Join Dr. Jeffrey Gladden and Tom Casey in this episode of the Gladden Longevity Podcast. Tom Casey is the Founder, Chairman, and Chief Executive Officer of Spectrum Plasma and is responsible for overseeing all aspects of the Company’s business.
Dr. Jeffery Gladden discusses with Dian Ginsberg MD, who has years of experience providing comprehensive obstetrics and gynecology treatment and is a functional medicine physician. They talk about young plasma, young plasma transfusion, and the various benefits.
